FUNGUARD
sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pe
CAS: 208538-73-2
Molecular Formula: C56H72N9NaO23S
FUNGUARD - Names and Identifiers
FUNGUARD - Physico-chemical Properties
| Molecular Formula | C56H72N9NaO23S |
| Molar Mass | 1294.28 |
| Melting Point | >180°C (dec.) |
| Solubility | H2O : 80 mg/mL DMSO : 30 mg/mL |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Use | Micafungin sodium a cyclic hexapeptide echinocandin lipopeptide. |
| Target | 1,3-beta-D-glucan synthesis |
| In vitro study | Micafungin is an antifungal agent that does not inhibit bacteria. Although it does not directly inhibit bacteria, it can improve the survival rate of G. mellonella. Micafungin inhibits biofilm formation by blocking the synthesis of 1,3-β-D-glucan in Candida albicans. |
FUNGUARD - Reference
| Reference Show more | 1. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23.2. Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12.3. Ikeda F, Wakai Y, Matsumoto S, et al. Efficacy of FK463, a new lipopeptide antifungal agent, in mouse models of disseminated candidiasis and aspergillosis. Antimicrob Agents Chemother. 2000;44(3):614-618.4. Tawara S, Ikeda F, Maki K, et al. In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi. Antimicrob Agents Chemother. 2000;44(1):57-62.5. Mikamo H, Sato Y, Tamaya T. In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide. J Antimicrob Chemother. 2000;46(3):485-487. |
FUNGUARD - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.774 ml | 3.869 ml | 7.738 ml |
| 5 mM | 0.155 ml | 0.774 ml | 1.548 ml |
| 10 mM | 0.077 ml | 0.387 ml | 0.774 ml |
| 5 mM | 0.015 ml | 0.077 ml | 0.155 ml |
Last Update：2024-01-02 23:10:35
FUNGUARD - Cell Experiment
Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24 h at 30°C. Cryptococcus neoformans YC203 is grown in YM broth medium for 20 h at 30°C with shaking at 200 r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline. A. fumigatus FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates, with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165 m MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated into each well to yield 1×105 CFU/well, and the plates are then incubated for 20 h or 48 h at 37°C. Two end points are determined by microscopic observation: MEC, which
Last Update：2023-08-16 21:32:38
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